DEVINE
Tissues, made up of specialised and immune cells, are essential to multicellular organisms. Understanding their formation, function and dysfunction during ageing or in pathologies such as cancer remains a major challenge.
The DEVINE Major Programme (Development and Immunology Network to unravel tissue biology) brings together developmental biologists and immunologists to explore the interactions between stem, specialised and immune cells in physiological and pathological contexts. It aims to integrate this knowledge to gain a better understanding of development, ageing and the transformations associated with disease, while developing innovative therapeutic approaches.
The main lines of research
- Exploring cellular interactions within tissues: analysing the dialogues between stem cells, specialised cells and immune cells in physiological and pathological contexts.
- Understanding the life continuum of tissues: studying their development, homeostasis, ageing and the mechanisms of cellular transformation associated with cancer.
- Developing innovative therapeutic approaches: using emerging knowledge to improve tissue function in the event of ageing or disease, and to counter the cellular transformations associated with cancer.
The project leaders
Institut Curie
- (U932)
- (UMR3215/U934)
- (UMR144)
- (U1330)
Collège de France
Ecole Normale Superieure - PSL
Establishments involved :
Institut Curie
Collège de France
Ecole Normale Supérieure - PSL